NAD+ for Beginners: What It Is, Why It Matters, and How to Start

What Is NAD+?

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell. It's essential for converting food into energy (ATP production), repairing damaged DNA, activating sirtuins (longevity-associated proteins), and regulating your circadian rhythm.

Why NAD+ Declines With Age

NAD+ levels drop approximately 50% between ages 20 and 50. This decline is driven by increased consumption (more DNA damage to repair), decreased production, and increased activity of CD38 — an enzyme that breaks down NAD+. Lower NAD+ is associated with metabolic dysfunction, neurodegeneration, and accelerated aging.

The Evidence for Supplementation

Animal studies show remarkable results: NAD+ repletion reversed age-related tissue decline, improved mitochondrial function, and extended healthy lifespan. Human studies are earlier-stage but promising — a 2024 randomized controlled trial showed improved physical function and cognitive scores in adults over 60.

How Clyne Delivers NAD+

Clyne offers medically supervised NAD+ therapy through subcutaneous injections (highest bioavailability), nasal spray (convenient for daily use), and topical cream (for skin health). Your provider monitors your response and adjusts dosing based on your biometric data from connected devices.

What Results to Expect

Weeks 1-2: subtle energy improvements. Weeks 3-4: enhanced focus and sleep quality. Months 2-3: improved skin quality, sustained energy, better recovery from exercise. Individual responses vary — your Clyne provider tracks your metrics to optimize your protocol.