Sildenafil (Viagra) and tadalafil (Cialis) are both PDE5 inhibitors that treat erectile dysfunction by increasing blood flow. They're equally effective overall, but their differences may make one a better fit for your lifestyle.
Sildenafil: The On-Demand Option
Works within 30-60 minutes and lasts 4-6 hours. Best taken on an empty stomach. Typical starting dose is 50mg. Ideal for planned sexual activity.
Tadalafil: The Long-Acting Option
Works within 30-45 minutes but lasts up to 36 hours. Can be taken with or without food. Also available as a daily low-dose (2.5-5mg) for continuous readiness.
Which Should You Choose?
If you prefer spontaneity, daily tadalafil may be ideal. If you prefer on-demand treatment with a shorter duration, sildenafil is typically better. Your Clyne provider can recommend the best option.
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This content is reviewed by Clyne's editorial team and grounded in published clinical evidence. Citations are listed at the end of each piece. Clyne Concierge translates the science; your physician makes all clinical decisions. We never fabricate trial data, patient stories, or outcomes.
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